Pioneering Medicines: Bioinformatics Co-Op

What you'd do

• Analyze single-nucleus (snRNA-seq) and single-cell datasets to characterize cell populations relevant to disease biology.
• Support disease genomics analyses, including variant interpretation and genotype-phenotype exploration, to inform target identification and validation.
• Build, adapt, and run computational pipelines (e.g., RNA-seq, single-nucleus/single-cell, WGS/WES) using tools such as Nextflow, Snakemake, or custom scripts.
• Apply statistical and machine learning methods to identify patterns in multi-omic and experimental data.
• Query and integrate data from internal and public databases (e.g., TCGA, GTEx, CCLE, GEO).
• Create clear visualizations and summaries to communicate findings to interdisciplinary project teams.
• Document methods and code to ensure reproducibility and support downstream use by the team, while learning core bioinformatic processes and best practices from the broader team.

What they want

• Currently enrolled in an undergraduate or Master's program in bioinformatics, computational biology, computer science, statistics, genetics, or a related field.
• Proficient in Python or R, with working knowledge of Unix/Linux and version control (Git).
• Familiarity with genomics or biological data types (NGS, single-cell, proteomics) preferred.
• Exposure to statistics, machine learning, or workflow tools (Nextflow, Snakemake, Docker) is a plus.
• Strong problem-solving skills, curiosity, and the ability to work independently and in a team.
• Clear written and verbal communication skills.

What you get

• Build alongside founders. You’ll work inside the same hypothesis-driven process Flagship uses to conceive and launch first-in-category companies.
• This can be the start of a longer story. Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
• Work alongside people who left the safe path. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.
• Take on real ownership. You're contributing to ventures that are still being defined. Your work can shape real decisions, not just support them.
• Be paid like the contributor you are. Compensation reflects the real work you take on.

About Flagship Pioneering · Co-Ops & Internships

Pioneering Medicines (PM) is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied m…