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Empress Therapeutics: Genomics Co-Op
Flagship Pioneering · Co-Ops & Internships
- Where
- Somerville, MA USA
- Posted
- Sep 3
We're looking for a Co-Op to join our Genomics team and contribute to the development of Empress's Integromyx and Perturb-seq platforms. This is a real opportunity to do meaningful bench work. You'll design and execute molecular cloning workflows, maintain mammalian cell cultures, and apply qRT-PCR for transcriptional profiling, with the potential to get hands-on with CRISPR-Cas9 cell line engineering.
You'll work as part of a cross-functional team where your contributions matter from day one. We're looking for someone who is curious, detail-oriented, and excited to develop their skills in a fast-moving environment.
What you'd do
- Design, generate, and validate plasmids using Golden Gate cloning and other synthetic biology methodologies
- Maintain mammalian cell cultures; perform transductions, transfections, and routine cell culture husbandry
- Produce lentiviral vectors to support cell line engineering workflows
- Apply qPCR/qRT-PCR and other molecular biology techniques to support research objectives
- Contribute to CRISPR-Cas9-based mammalian cell line engineering experiments
- Present findings in team and cross-functional meetings; maintain meticulous electronic lab notebook records
What they want
- Currently enrolled in a B.S. or M.S. program in Molecular Biology, Genetics, Biochemistry, or a related field
- Coursework or hands-on laboratory experience in molecular biology, nucleic acid manipulation, or synthetic biology
What you get
- Build alongside founders. You’ll work inside the same hypothesis-driven process Flagship uses to conceive and launch first-in-category companies.
- This can be the start of a longer story. Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
- Work alongside people who left the safe path. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.
- Take on real ownership. You're contributing to ventures that are still being defined. Your work can shape real decisions, not just support them.
- Be paid like the contributor you are. Compensation reflects the real work you take on.
About Flagship Pioneering · Co-Ops & Internships
Empress Therapeutics is pioneering mechanistic intelligence for drug discovery — helping R&D teams understand what their molecules are doing, what is driving activity, what liabilities may emerge, and which candidates are best positioned to advance. By integrating multi-omics, chemoproteomics, proteomics, transcriptomics, computational inference, knowledge graphs, and CRISPR-based functional validation, Empress turns biological complexity into clearer development decisions.