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Internship
Apriori Bio: Protein Science Co-Op
Flagship Pioneering · Co-Ops & Internships
- Where
- Cambridge, MA USA
- Posted
- 3 days ago
As a member of our protein science team, you’ll help turn computationally designed vaccine immunogens into well-characterized proteins. Our team produces antigens in multiple formats for antigen validation and in-vivo studies, and develops the assays used to characterize and functionally validate them.
We're Looking For:
Highly motivated and enthusiastic co-op students for a six-month position, eager to dive into hands-on protein science.
Individuals with a background in biochemistry, molecular biology, or bioengineering and a desire to master protein expression, purification, and characterization.
What You'll Do:
What you'd do
- Express recombinant vaccine antigens and antibodies in mammalian expression systems, including small-scale transient transfection and scale-up.
- Purify proteins using affinity and size-exclusion chromatography on ÄKTA systems.
- Characterize protein quality and stability using SDS-PAGE, analytical SEC, and thermal stability methods such as DSF.
- Contribute to the development and execution of binding and functional assays, including ELISA and bio-layer interferometry (BLI), to assess antigenicity against panels of monoclonal antibodies.
- Document experiments in our electronic lab notebook (Benchling) and present results at team meetings.
What they want
- Pursuing a BS or MS in Biochemistry, Bioengineering, Chemical Engineering, Molecular Biology, or a related field
- Hands-on laboratory experience (coursework or research), such as SDS-PAGE, solution preparation, and accurate pipetting
- Experience with mammalian cell culture and aseptic technique
- Preferred: exposure to protein purification/chromatography or plate-based assays such as ELISA
- Strong organizational, record-keeping, and communication skills
What you get
- Be part of an inspiring mission to protect against viral threats globally.
- Collaborate with a dynamic team of experimental and computational scientists.
- Gain hands-on experience across the full path from computational antigen design to validated protein ready for in-vivo studies.
- Develop a diverse skill set and gain unparalleled experience in cutting-edge research.
- Agile mindset - we adapt quickly, stay curious, and move with our fast-evolving science.
- Relentless drive – we're passionately dedicated to our mission and push to make the impossible possible.
- Grit – we stay determined through hard problems and see the work through.
- Build alongside founders. You’ll work inside the same hypothesis-driven process Flagship uses to conceive and launch first-in-category companies.
- This can be the start of a longer story. Strong co-ops are considered for future opportunities across Flagship and its portfolio companies, not just for this one role.
- Work alongside people who left the safe path. Your colleagues are scientists, engineers, and operators who chose to build something new rather than join something already established.
About Flagship Pioneering · Co-Ops & Internships
Apriori Bio was founded by Flagship Pioneering’s venture creation engine that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value.